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Causes of increase and decrease in creatinine in the blood
Last reviewed: 23.04.2024
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The content of creatinine in the blood naturally increases with renal failure, which is of great importance for its diagnosis. The diagnosis of acute renal failure is set at a serum creatinine concentration of 200-500 μmol / L (2-3 mg%), an increase of 45 μmol / l (0.5 mg%) with a baseline value below 170 μmol / l (< 2 mg%) or when the creatinine level is increased 2 times as compared with the baseline. In severe acute renal failure, the serum creatinine concentration is greater than 500 μmol / L (> 5.5 mg%).
It should be noted that an increase in the concentration of creatinine and urea in the blood with acute renal failure is a rather late signs. They occur when more than 50% of nephrons are affected. In severe acute renal failure, the content of creatinine in the blood can reach 800-900 μmol / l, and in some cases 2650 μmol / l and above. In uncomplicated cases of acute renal insufficiency, the concentration of creatinine in the blood increases per day by 44-88 μmol / l, in cases of acute renal failure accompanied by muscle damage (extensive trauma), the level of creatinine in the blood increases more markedly as a result of a significant increase in the rate of its formation. The concentration of creatinine in the blood and GFR is used as the main laboratory criteria in the classification of chronic renal failure.
It should be remembered that such diseases as hyperthyroidism, acromegaly, gigantism, diabetes, intestinal obstruction, muscular dystrophy, extensive burns, can also be accompanied by an increase in the concentration of creatinine in the blood.
Laboratory criteria of stages of chronic renal failure and creatine content in the blood
The clearance of endogenous creatinine
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