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Endogenous creatinine clearance (Reberg-Tareyev test)
Last reviewed: 04.07.2025
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The Reberg-Tareev test allows one to judge glomerular filtration and tubular reabsorption in the kidneys. The test is based on the fact that creatinine is filtered only by the glomeruli, is practically not absorbed and is secreted by the tubules in insignificant quantities. The procedure for conducting the test is as follows: the patient urinates in the morning, drinks 200 ml of water and then, on an empty stomach, in a state of complete rest, collects urine for a precisely defined short period of time (2 hours). In the middle of this period of time, blood is taken from a vein. The concentration of creatinine in the blood and urine collected for 2 hours is determined. The clearance coefficient (C och ) or endogenous creatinine clearance is calculated:
K och = (M/Pl.) x D (ml/min),
Where M is the concentration of creatinine in urine; Pl. is the concentration of creatinine in plasma; D is the minute diuresis in ml/min [equal to the amount of urine excreted in 2 hours (ml) divided by 120 min). K och expresses the SCF. To determine the SCF, urine collected over a day can be analyzed.
Normally, the SCF is 120+25 ml/min for men and 95+20 ml/min for women. SCF values are lowest in the morning, increase to maximum values during the day, and then decrease again in the evening. In healthy people, a decrease in SCF occurs under the influence of heavy physical exertion and negative emotions; it increases after drinking liquid and eating high-calorie foods.