Benign lymphoplasia of the skin: causes, symptoms, diagnosis, treatment

Benign lymphoplasia of the skin (synonyms: benign lymphadenosis of Beufverstedt, lymphocytes, lymphoid hyperplasia of the skin, etc.).

Causes and pathogenesis of benign lymphoplasia of the skin. Provoking factors are insect bites, inhalation, trauma, shingles, etc. It is possible that benign lymphoplasia develops in patients with scabies, which is called post-scabious lymphoplasia of the skin. It is believed that the onset of the disease is associated with reactive hyperplasia of embryonic lymphoid tissue.

The immune system plays an important role in the pathogenesis of the disease, since infiltration by macrofoci and lymphoid cells is observed at the site of the lesion.

Symptoms of benign lymphoplasia of the skin. Benign lymphoplasia can develop at any age, in both men and women.

Symptoms of the disease are characterized by the appearance of nodules, plaques or infiltrative-tumor elements, located mainly on the skin of the face, mammary glands, genitals, armpits. The nodules have a hemispherical shape, round or oval outlines with clear boundaries, a dense-elastic consistency, a smooth or scaly surface of a bluish-pink color. The number of nodules varies from single to multiple, which is especially typical for postscabies lymphoplasia. Spontaneous regression of the rash is often noted, in place of which hyperpigmented spots may remain, gradually disappearing. In the tumor form, tumors have different sizes - from beans to cherries and more, a dense-elastic consistency. The color of the tumors is initially pink-red, then acquires a bluish-pink tint. Tumors are usually embedded in the skin and subcutaneous tissue, closely fused with the skin, and are mobile in relation to the underlying tissues when palpated. There are solitary and disseminated variants of the location of nodes and nodules.

Infiltrative-tumor-like formations of a reddish-brown color have a round shape with sharp boundaries and a doughy consistency.

Sometimes itching is possible. Different clinical forms of benign lymphoplasia of the skin may be observed in one patient.

Histopathology. Histologically, a dense, large-focal infiltrate is observed in the dermis, which is separated from the epidermis by a narrow strip of unchanged collagen. The infiltrate consists of lymphocytes, histiocytes, plasma cells, and eosinophilic granulocytes. The structure of the infiltrates resembles primary and secondary follicles of the lymph nodes. Sometimes a granulomatous structure is observed.

Differential diagnosis. Benign cutaneous lymphoplasia must be differentiated from eosinophilic granuloma of the face, limited lymphangioma, sarcoidosis, trichoepithelioma, lymphosarcoma, discoid lupus erythematosus.

Treatment of benign lymphoplasia of the skin. Non-steroidal anti-inflammatory drugs (indomethacin, voltaren) and corticosteroids (injections and under an occlusive dressing) are prescribed. A good effect is observed when using X-ray therapy and antibiotics.

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