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Hepatitis G test: IgG antibodies to HGV in blood
Last reviewed: 05.07.2025
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Viral hepatitis G is an infectious disease with a parenteral mechanism of infection (mainly through blood transfusions). The hepatitis G virus (HGV) belongs to the Flaviviridae family. The virus genome is represented by single-stranded RNA. Currently, it is assumed that there are at least three genotypes and several subtypes of HGV, distributed according to their geographic origin. The virus contains a lipid membrane that serves as an obstacle to the formation of immune complexes antigen-antibody during the persistence of the virus in the human body. Clinical manifestations of the disease are less pronounced compared to other forms of viral hepatitis. Only 30-50% of those infected with viral hepatitis G have an increase in the activity of transaminases in the blood serum.
The main laboratory marker of viral hepatitis G is the detection of viral RNA in the blood using the PCR method. For retrospective diagnostics of viral hepatitis G, it is possible to use the detection of specific IgG class AT to the E2 HGV envelope protein in the blood serum.
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