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Aggregation of platelets with collagen
Last reviewed: 06.07.2025
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Collagen-induced platelet aggregation has a fairly pronounced latent phase, during which phospholipase C is activated. Depending on the reagent used, the duration of this phase can be 5-7 minutes. After this period, processes occur in platelets that lead to the formation of secondary messengers, resulting in the secretion of platelet granules and the synthesis of thromboxane A 2, which is accompanied by a sharp increase in interplatelet interaction.
In laboratory and clinical practice, collagen is most often used in a final concentration of 50 μg/ml, however, collagens from different companies may have different activities, which must be taken into account when using them. The results of the study of platelet aggregation capacity can be expressed as a percentage.
This study is not used separately, but is carried out in combination with the determination of platelet aggregation with ADP and adrenaline.
Weiss Platelet Aggregation Reference Values for Collagen
Collagen concentration, μg/ml |
Aggregation is normal,% |
10 |
93.1 |
5 |
75.0 |
2 |
69.4 |
1 |
46.4 |
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