Aggregation of platelets with adrenaline
Last reviewed: 23.04.2024
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The curve recorded when recording adrenaline-induced platelet aggregation has two waves. Adrenaline in contact with platelets interacts with α 2 -adrenoreceptors, which causes inhibition of adenylate cyclase. It is not excluded that the mechanism underlying the realization of the effect of adrenaline and the development of the first aggregation wave does not depend on the formation of thromboxane A 2, the release or synthesis of the platelet aggregation factor, but is related to the ability of this proagregant to directly change the permeability of the cell membrane for Ca 2+ ions. Secondary aggregation during the induction of the process with adrenaline occurs as a result of the release reaction and production of thromboxane A 2. The results of the study of platelet aggregation capacity can be expressed as a percentage.
Separately, the study is not applied, but carried out in conjunction with the determination of platelet aggregation with ADP and collagen.
The reference values of platelet aggregation according to Weiss for epinephrine
|
Adrenaline, μmol |
Aggregation is normal,% |
|
300 |
92.5 |
|
150 |
46.0 |
|
60 |
42.5 |
|
Thirty |
35.0 |
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