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Allergic intestinal lesions: causes
Last reviewed: 23.04.2024
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Intestines can serve as input gates for penetration into the body of various exogenous allergens (food, chemical, medicinal, parasitic, etc.). In the intestinal wall, antibodies fixed in them can be observed and antigens administered by various routes into the body (inhalation, subcutaneous, intravenous) cause the immunological process, as a result of which a variety of functional intestinal lesions occur. In other words, intestines can be a "shock" organ in which the antigen-antibody reaction develops when the organism is sensitized parenterally.
So, with serum sickness, bronchial asthma, hay fever, urticaria, Quinck's edema, drug allergy, there are violations of the functions of intestines of an allergic nature. On the other hand, inflammatory and atrophic changes in the intestinal mucosa increase the likelihood of absorption of food and drug antigens and favor secondary sensitization of the body. In this case, a decrease in production of secretory IgA, which normally prevents penetration of exoantigens through the intestinal wall, may play a role. Allergic bowel disease most often occurs with food and drug allergies, as well as on the basis of sensitization to automicroflora.
Allergic entero-and colopathy can develop again on the soil of dysbacteriosis, chronic enteritis, colitis, cholecystitis due to sensitization to automicroflora, tissue antigens, and especially often to food antigens and various food additives (preservatives, dyes, antibacterial substances, etc.).
Consequently, intestinal dysfunctions in some cases are a consequence and manifestation of a common allergosis, in others - an allergic component can be an important pathogenetic factor of the chronic pathological process in the organ of the most diverse etiology.
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