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Endocrinologist

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The causes of increase and decrease of renin

Alexey Portnov, medical expert
Last reviewed: 19.10.2021

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Diseases and conditions in which the renin activity in the blood plasma can change

Renin downgraded

Excessive salt intake
Defeat of the adrenal cortex: primary hyperaldosteronism; bilateral adrenal hyperplasia; adrenal cancer
Hypertensive disease with low renin level
Acute kidney failure
Liddle Syndrome
The use of diuretics, glucocorticosteroids, prostaglandins, estrogens

Renin is promoted

Secondary hyperaldosteronism
Malignant neoplasm of kidney parenchyma
Diseases of the liver (hepatitis, cirrhosis)
Primary insufficiency of the adrenal cortex (Addison's disease)
Right ventricular failure
Nephrosis, nephropathy
Narrowing of the renal artery
Activation of the sympathetic nervous system
Kidney cancer with hyperreneinemia
Neuroblastoma
Bartter's syndrome (hyperplasia of juxtaglomerular cells)