The reasons for the increase and decrease in B-lymphocytes (CD20)
Last reviewed: 19.10.2021
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In the second half of the normally developing inflammatory process, in most cases the relative amount of B-lymphocytes in the blood rises (especially in viral infections). As a rule, this indicator increases in parallel with the increase in regional lymph nodes. The relative content of B-lymphocytes usually increases with prolonged inflammatory processes. For the clinician, the most important is the analysis of the level of B lymphocytes after the end of the clinical manifestations of the inflammatory process. In all cases, the normalization of the relative amount of B-lymphocytes indicates a complete end of the process.
Diseases and conditions in which the amount of CD20 lymphocytes in the blood changes
| Increase in the | Decrease in the indicator |
|
Acute bacterial, fungal and parasitic infections HIV infection (initial period) Chronic liver disease, cirrhosis, viral hepatitis Autoimmune diseases Rheumatoid arthritis Systemic lupus erythematosus Rheumatism, collagenoses Sarcoidosis, cystic fibrosis Waldenström's disease Infectious mononucleosis Chronic lymphatic leukemia Monoclonal Gammopathy Acute period of re-infection, immune response to thymus-independent antigens |
Physiological hypogammaglobulinemia in children (aged 3-5 months) Congenital hypogammaglobulinemia or agammaglobulinemia Neoplasms of the immune system Treatment with cytostatics and immunosuppressants Condition after removal of spleen Insufficiency of humoral immunity |