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Total number of B-lymphocytes (CD20) in the blood
Last reviewed: 05.07.2025
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The total number of CD20 lymphocytes in the blood for adults is normally 8-19%, absolute values are 0.19-0.38x10 9 /l.
CD20 lymphocytes are humoral immunity cells responsible for antibody synthesis. They are formed in the bone marrow from stem cells, where they undergo the first stages of differentiation. According to modern concepts, the development of B lymphocytes occurs in stages from a stem cell to early and late precursors and, finally, to a mature cell. B lymphocytes are mainly concentrated in peripheral lymphoid organs. Peripheral blood contains only 15-20% of their total number. The ratio of populations in the total pool of B lymphocytes is of great importance in assessing humoral immunity: B lymphocytes with IgM receptors make up 3-10%; with IgG receptors - 2-6%, with IgA receptors - 1-3%. Many diseases are associated with an imbalance in the ratio of B lymphocytes. B-cell deficiency leads to severe immunodeficiencies, and their excessive activity leads to the development of autoimmune pathology.
It should be noted that the number of B-lymphocytes in the peripheral blood is a fairly stable indicator of homeostasis, changing little under various influences, therefore, a deviation of its value from the normal can serve as one of the important criteria of immunopathology.