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Aggregation of platelets with arachidonic acid
Last reviewed: 23.04.2024
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Arachidonic acid is a natural aggregation agonist, and its action is mediated by the effects of prostaglandins G 2 and H 2 and thromboxane A 2 and involves activation of both phospholipase C followed by the formation of secondary mediators, mobilization of intracellular calcium and expansion of the cell activation process, and phospholipase A 2, which directly leads to the release of endogenous arachidonic acid.
Activation of platelets under the action of arachidonic acid occurs quickly enough, therefore, the curve characterizing this process is more often of a single-wave nature.
For the induction of platelet aggregation, arachidonic acid is used in concentrations of 1 × 10 -3 -1 × 10 -4 mol. When working with arachidonic acid, it should be borne in mind that in air this substance is very rapidly oxidized.
A sample of platelet aggregation with arachidonic acid is recommended in cases of drugs that affect the aggregation reaction (for example, acetylsalicylic acid, penicillin, indomethacin, deligil, diuretics), which should be taken into account when evaluating the results of the studies.
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