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Gamma glutamyl transpeptidase in the blood
Last reviewed: 23.04.2024
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Reference values (norm) of activity of γ-glutamyl transpeptidase (GGTP) in blood serum: in men - 10,4-33,8 IU / l; in women - 8.8-22 IU / liter.
Gamma glutamyl transpeptidase is a membrane enzyme consisting of hydrophilic and hydrophobic fragments with a molecular mass ranging from 90,000 to 120,000. Glutamyl transpeptidase is found in significant amounts in the liver, pancreas, kidneys and prostate gland (therefore in men the activity of gamma glutamyl transpeptidase in serum approximately 50% higher than in women). In other tissue cells, gamma glutamyl transpeptidase is present in small amounts (excluding cardiomyocytes and myocytes). A small part of the enzyme is in the cytosol, and most of it is associated with the microsome membranes and the cytoplasmic membrane of the cells.
In general, the activity of gamma glutamyl transpeptidase is high on the membranes of cells possessing high secretory or absorbing capacity, such as bile duct epithelial cells, kidney proximal tubule cells, pancreatic acinar tissue and its ducts, and brushing of intestinal cells. Gamma glutamyl transpeptidase easily forms complexes with HDL and LDL, with HDL bound to gamma glutamyl transpeptidase mainly in the intact liver, and LDL - in hepatic jaundice.
The half-life in the blood serum of gamma glutamyl transpeptidase associated with HDL is 20 h, and the soluble form of gamma glutamyl transpeptidase is 9 h.
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