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Glutamate dehydrogenase in blood
Last reviewed: 04.07.2025
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Reference values (norm) for glutamate dehydrogenase activity in blood serum are less than 4 IU/L.
Glutamate dehydrogenase catalyzes the conversion of glutamic acid to alpha-ketoglutaric acid and ammonia; the enzyme is concentrated in the mitochondria of cells, primarily in hepatocytes. It is also found in small amounts in nervous tissue, skeletal muscle, myocardium, and mammary gland.
Glutamate dehydrogenase is one of the organ-specific enzymes, determined in the blood serum in liver diseases.
Since the enzyme is mitochondrial, the degree of increase in its activity reflects the depth of cytolysis in liver diseases; its level can be used to judge the severity of the pathological process.
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