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Treatment of dyspepsia
Last reviewed: 06.07.2025
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The basis of treatment of dyspepsia and acute infections accompanied by dehydration is rehydration therapy. It is carried out in order to restore the water-electrolyte and acid-base balance of the body.
Rehydration is carried out with polyionic crystalloid solutions (trisol, chlosol, acesol). Colloidal solutions (hemodez, rheopolyglucin) can be used for detoxification purposes only in the absence of dehydration. In most patients with I-II degrees of dehydration, solutions of oral rehydration salts are used: citraglucosolan, glucosolan, rehydron. Rehydration therapy is the basis for the treatment of acute infections accompanied by dehydration syndrome.
Rehydration therapy (intravenous and oral) is carried out in two stages.
- Elimination of existing fluid losses. The volume of administered solutions as a percentage of body weight corresponds to the degree of dehydration, the rate of administration also depends on the degree of dehydration (from 30-40 ml/min at degree I to 120-130 ml/min at degree IV).
- Correction of ongoing fluid losses.
In addition to rehydration, the following groups of drugs are used to correct gastrointestinal disorders in infectious diseases.
- Sorbents (polyphepan, 1 tablespoon 3-4 times a day, polysorb, carbolong, etc.) to reduce intoxication.
- Smecta (dioctahedral smectite) is a multi-purpose drug (sorbent and protector that protects the intestinal mucosa). Take 3-4 packets (9-12 g) per day.
- Eubiotics (Linex 2 capsules 3 times a day, Bifidumbacterin Forte, Acipol, Biosporin, etc.).
- Enzyme preparations - Oraza, Abomin, Pancreatin, etc. - 1 tablet (dragee) 3 times a day during meals.
- Metoclopramide, a dopamine receptor blocker, is used at 10 mg 1-3 times a day intramuscularly for 1-2 days to reduce vomiting and dyspeptic disorders.
- Antispasmodics for pain syndrome: drotaverine 0.04 g 3 times a day orally or 1 ml of 2% solution intramuscularly 1-2 times a day; papaverine; belladonna preparations (bellastezin, besalol).
- Indomethacin is an inhibitor of prostaglandin biosynthesis, which helps stop secretory diarrhea. Prescribed at 50 mg 3 times at 3-hour intervals for 1 or 2 days.
- Octreotide is an inhibitor of the synthesis of active secretory agents, which helps reduce secretion and motor activity. It is available in ampoules of 0.05, 0.1 and 0.5 mg. It is administered subcutaneously 1-2 times a day.
- Calcium preparations that activate phosphodiesterase, which prevents the formation of cAMP. It is recommended to use 0.5 g of calcium gluconate per os 2 times with an interval of 12 hours.
- Intestinal antiseptics, effective against a wide range of gram-positive and gram-negative bacteria, dysenteric amoebae and Candida fungi:
- Intetrix 1-2 capsules 3 times a day;
- Enterol is an antidiarrheal drug of biological origin (obtained from the yeast Saccharomyces boulardii) prescribed 1-2 capsules 2 times a day.
- Antibiotics and fluoroquinolones are used to treat four intestinal infections: cholera, shigellosis, yersiniosis and campylobacteriosis.