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T-lymphocytes with receptors to interleukin-2 (CD25) in blood
Last reviewed: 05.07.2025
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Normally, the number of CD25 lymphocytes in the blood of adults is 13-24%.
CD25 - activated T-lymphocytes that stimulate antibody formation and cytotoxicity. This indicator reflects the ability of lymphocytes to proliferate and differentiate and characterizes the functional state of activated T-lymphocytes. A reduced number indicates immunological insufficiency of the cellular link of immunity. With hyperactivity of the immune system, the number of these cells increases.
Diseases and conditions that lead to changes in the number of CD25 lymphocytes in the blood
Increase in the indicator
- Hyperactivity of the immune system in allergic and autoimmune diseases
- Activation of anti-transplant immunity, crisis of rejection of donor organs in recipients
- Immune response to thymus-dependent antigens
- In the acute period of primary infection
Decrease in the indicator
- Oncological diseases
- Secondary immunodeficiency states, HIV infection
- Congenital defects of the immune system
- Severe viral infections
- Severe burns, injuries, stress
- Treatment with cytostatics and immunosuppressants
- Ionizing radiation
- Taking glucocorticosteroids