Symptoms of lymphogystyocytosis
Last reviewed: 23.04.2024
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The initial symptoms of lymphohistiocytosis are numerous and nonspecific: fever accompanied by symptoms of gastrointestinal pathology or viral infection, progressive hepatosplenomegaly, lymphadenopathy, nonspecific rash, jaundice, edema, symptoms of CNS damage, rarely hemorrhagic syndrome.
Thus, symptoms such as: prolonged hectic fever with spontaneous regression in some patients, refractory to antibacterial therapy; rapidly enlarges the size of the spleen, often in combination with increased liver size. All other manifestations are detected significantly less frequently, on average in a third of patients. Among them: transient maculopapular rash, widespread lymphadenopathy of moderate severity, in the absence of conglomerates and adhesion of lymph nodes between themselves and surrounding tissues; neurologic symptoms in the form of increased excitability, vomiting, seizures, signs of intracranial hypertension and delayed psychomotor development.
Together with the tech, a small part of the patients shows such formidable neuropathic symptoms as rigidity of the occipital muscles, opisthotonus, paresis and paralysis, acute loss of vision and consciousness. In single reports there are data on lung lesions, represented by interstitial changes.
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