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Stevens-Johnson Syndrome in children
Last reviewed: 23.04.2024
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[The symptoms of Stevens-Johnson syndrome and
The onset of acute, high fever, severe intoxication, arthraltia, myalgia and from the first hours is characterized by progressive skin lesions. On the skin of the face, neck, chest, limbs (including the palms and soles), there are dark red spots with rapid formation of vesicles, or with particularly severe flow of bullous elements with serous-bloody contents. Vesicles and bullae on the skin are opened, forming erosions and ulcers. Rashes on the skin tend to merge. In most patients, mucous membranes are also affected: conjunctivitis with keratitis, stomatitis, pharyngitis, laryngitis. Girls often suffer from vulvar damage. Often secondary infection develops on the skin or in the airways and lungs. Other internal organs are usually not affected.
A sick child is urgently hospitalized; put in a separate box. The suspect drug is canceled. Assign enterosorbents (activated carbon, polyphepan, polyphene, smektu).
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Treatment of Stevens-Johnson syndrome
Prescribe prednisolone 1-2 mg / kg / day, infusion detoxification therapy - 5% glucose solution with isotonic sodium chloride solution. In an acute period of severe course, prednisolone at a dose of 3-5 mg / kg / day can be administered intravenously. Vascular drugs and disaggregants are prescribed (euphyllin, pentoxifylline, ticlopedin), antiproteolytic drugs - gordoks, kontrikal, trasilol. When bacterial infection is attached, antibiotics are prescribed, taking into account the results of bacteriological examination.
Local treatment of erosions and ulcers is similar to the treatment of burns by the open method with the use of indifferent antiseptic agents and keratoplastic. If the eyes are affected, ocular hydrocortisone ointment is poured 3-4 times a day.
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