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Reasons for increasing the MB fraction of creatine kinase
Last reviewed: 19.10.2021
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The presence of the BB fraction in the blood can simulate an increase in the MB fraction, up to an excess of MB-fraction activity over the total creatine kinase. CC-BB appears when the blood-brain barrier is broken (after brain operations or trauma). BB-fraction also appears with serious damage to the intestine and after childbirth (especially with caesarean section).
Increase in the activity of total creatine kinase and MB-fraction is revealed after operations or diagnostic manipulations on the heart. Radiation therapy of the breast area can also cause a slight hyperfermentation. Tachyarrhythmia or heart failure rarely cause an upsurge in creatine kinase and KK-MB activity.
Increase of the fraction of KK-MB in some cases is possible with myocarditis and myocardial dystrophies, however, it usually accounts for less than 3% of the total creatine kinase.
Damage to the skeletal muscles is accompanied by a significant increase in the activity of the MM-fraction, which can "simulate" the MB-fraction. With rhabdomyolysis, the diagnostic sensitivity of the study of the activity of creatine kinase (increased 5-fold or more) is higher than that of aldolases, AST and LDH.
Diseases and conditions accompanied by increased activity of creatine kinase and CC-MB in serum
- Physical stress and muscle trauma.
- Increased muscle mass as a result of exercise.
- Physical stress (overload).
- Surgical interventions, direct trauma, intramuscular injection.
- Acute psychosis, acute brain damage, coma (necrosis of muscles with bedsores).
- Spasms (epilepsy, tetanus), childbirth.
- Severe burns; electric shock.
- Degenerative and inflammatory lesions.
- Muscular dystrophy.
- Myositis (collagenoses, viral infections, trichinosis).
- Myocarditis.
- Toxic muscle damage.
- Acute alcohol poisoning, white fever.
- Exogenous intoxication (bromides, barbiturates, carbon monoxide).
- Tetany.
- Medications (clofibrate, bronchodilators).
- Toxic rhabdomyolysis (heroin, amphetamines).
- Malignant hyperthermia.
- Metabolic muscle damage.
- Hypothyroidism.
- Metabolic rhabdomyolysis (hypokalemia, hypophosphatemia, hyperosmolar conditions).
- Glycogenosis (type V).
- Hypoxic lesions of muscles: shock, peripheral embolism, hypothermia.