Medical expert of the article
New publications
Pseudotuberculosis: antibodies to the causative agent of pseudotuberculosis in blood
Last reviewed: 05.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
The diagnostic titer of antibodies to the pseudo-tuberculosis pathogen in the blood serum for RPGA is 1:100 or higher.
Pseudotuberculosis (Far Eastern scarlet fever-like fever) is an acute infectious disease classified as an alimentary zoonoses. The causative agent of pseudotuberculosis is Yersinia pseudotuberculosis, a gram-negative bacillus, belonging to the enterobacteria family. There are 6 serovariants (I-VI) of Yersinia pseudotuberculosis. The human disease is most often caused by Yersinia I, less often by III and IV serovariants. Pseudotuberculosis is characterized by general intoxication, scarlet fever-like rash, gastrointestinal tract and joint damage. Serological testing is the main method of laboratory diagnostics of pseudotuberculosis, since bacteriological testing of feces, urine, sputum, cerebrospinal fluid, and bile requires a long time (15-28 days) and gives a positive result in 15-30% of cases.
Determination of the titer of antibodies to the pseudo-tuberculosis pathogen in serum is a retrospective method for diagnosing pseudo-tuberculosis. Paired sera of the patient are examined. To identify specific antibodies, blood is taken for examination at the onset of the disease and 7-10 days after the initial examination. A diagnostic sign of pseudo-tuberculosis is an increase in the antibody titer after 7-10 days by at least 4 times or a single titer of 1:100 or higher. RPGA is a highly specific method that gives positive results in more than 80% of patients. Antibodies are detected using RPGA already in the first week of the disease.
Determination of antibodies to the pseudo-tuberculosis pathogen is used to diagnose pseudo-tuberculosis, including bacterial arthritis, Reiter's disease, Behcet's syndrome, and infectious arthropathies.
[