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Pseudotuberculosis: antibodies to the causative agent of pseudotuberculosis in the blood

Alexey Portnov, medical expert
Last reviewed: 23.04.2024

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The diagnostic titer of antibodies to the causative agent of pseudotuberculosis in the serum for RPGA is 1: 100 and higher.

Pseudotuberculosis (Far Eastern scarlet fever-like fever) is an acute infectious disease attributable to nutritional zoonoses. Pathogen pseudotuberculosis - Yersinia pseudotuberculosis, gram-negative rod, belongs to the family of enterobacteria. There are 6 serovariants (I-VI) of Yersinia pseudotuberculosis. Disease of a person is most often caused by iersinia I, rarely III and IV serovariants. Pseudotuberculosis is characterized by general intoxication, scarlet fever, lesions of the gastrointestinal tract and joints. Serologic examination is the main method of laboratory diagnosis of pseudotuberculosis, as bacteriological examination of feces, urine, sputum, liquor, bile takes a long time (15-28 days) and gives a positive result in 15-30% of cases.

Determination of antibody titer to the causative agent of pseudotuberculosis in the serum is a retrospective method for diagnosing pseudotuberculosis. The paired sera of the patient are examined. To identify specific antibodies, blood is taken to the study at the onset of the disease and 7-10 days after the initial examination. The diagnostic sign of pseudotuberculosis is considered to increase the antibody titer 7-10 days by no less than 4 times or a one-time titer of 1: 100 and higher. RPHA is a highly specific method that yields positive results in more than 80% of patients. Antibodies with the help of RPGA are detected already in the first week of the disease.

Determination of antibodies to the causative agent of pseudotuberculosis is used to diagnose pseudotuberculosis, including bacterial arthritis, Reiter's disease, Behcet's syndrome, infectious arthropathies.

trusted-source [1], [2], [3], [4]

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