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Ovarian antibodies in the blood
Last reviewed: 23.04.2024
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Normally, there are no ovarian antibodies in the blood serum.
Ovarian antibodies (to ovarian cell antigen) were first detected in women with premature menopause, infertility and in vitro fertilization . This group of antibodies can include antibodies to Leidig cells, ovarian granulosa cells and placental syncytiotrophoblast. To determine antibodies to germ cells, the method of indirect immunofluorescence and ELISA (allows to determine the total antibodies and antibodies of different classes - IgM, IgG, IgA). These antibodies can be found in the blood of women many years before the development of clinical manifestations of premature ovarian failure.
In addition to ovarian antibodies, ELISA can detect antibodies to the transparent oocyst shell (zona pellucida), which are total and belonging to different classes of Ig (IgM, IgG, IgA), which have the same diagnostic value as ovarian antibodies.
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