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Ovarian antibodies in the blood
Last reviewed: 05.07.2025
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Normally, ovarian antibodies are absent in the blood serum.
Ovarian antibodies (to ovarian cell antigens) were first detected in women with premature menopause, infertility, and in vitro fertilization. This group of antibodies may include antibodies to Leydig cells, ovarian granulosa cells, and placental syncytiotrophoblasts. Indirect immunofluorescence and ELISA (allows for detection of total antibodies and antibodies of different classes - IgM, IgG, IgA) are used to determine antibodies to germ cells. These antibodies can be detected in women's blood many years before the development of clinical manifestations of premature ovarian failure.
In addition to ovarian antibodies, the ELISA method allows the detection of antibodies to the transparent membrane of the oocyst (zona pellucida) - total and related to various classes of Ig (IgM, IgG, IgA), which have the same diagnostic value as ovarian antibodies.
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