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Myeloperoxidase deficiency: causes, symptoms, diagnosis, treatment
Last reviewed: 23.04.2024
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Deficiency of myeloperoxidase is the most common congenital pathology of phagocytes, the incidence of complete hereditary myeloperoxidase deficiency is from 1: 1,400 to 1:12 000.
Hereditary deficiency of myeloperoxidase. The type of inheritance is autosomal recessive. Defects can be in structural or regulatory genes with a large variability of mutations. Myeloperoxidase is involved in the optimization of oxygen-dependent cytotoxicity, modulates the inflammatory response. Partial deficiency can be hereditary or acquired. Even with complete absence of myeloperoxidase, the phagocytosis and bactericidal activity of neutrophils are not violated, since for the destruction of microorganisms an MPO-independent system is used. At the same time, patients do not have candidal killer activity.
Hereditary deficiency of myeloperoxidase is asymptomatic, but there is a tendency to fungal infection, especially in patients with diabetes - to invasive mycoses.
With the deficiency of myeloperoxidase, treatment of infections is carried out according to general principles. Carefully prescribe antibiotics, especially with long courses. The forecast is favorable.
Prevention of myeloperoxidase deficiency is not carried out.
[What tests are needed?
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