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Insulin-like growth factor I in the blood

 
, medical expert
Last reviewed: 18.10.2021
 
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Insulin-like growth factor I in serum

The main factor determining the concentration of IGFR I in the blood serum is age. The concentration of IGFR I in the blood increases from very low values (20-60 ng / ml) at birth and reaches peak values (600-1100 ng / ml) during puberty. Already in the second decade of a person's life, the level of IGFR I begins to decline rapidly, reaching average values (350 ng / ml) at the age of 20 years, and then decreases more slowly with each decade. At 60 years, the concentration of IGFR I in the blood is not more than 50% of that at the age of 20 years. Daily fluctuations in the concentration of IGFR I in the blood were not detected.

Conditions affecting the concentration of blood glucose in the blood

Increase in concentration

Reduction in concentration

Acromegaly and Gigantism

Starvation, stress, alcoholism

Chronic kidney failure

Post-traumatic and postoperative conditions Porphyria, hyperglycemia Ectopic production by tumors of the stomach, lungs Hyperpituitarism Physical activity ACTH, vasopressin, estrogens, noradrenaline, dopamine, serotonin, clonidine, propranolol, bromocriptine, arginine, insulin, vitamin PP, amphetamine

Pituitary dwarfism

Hypercortisy

Obesity

Chemotherapy, radiotherapy

Operative interventions Syndrome Itenko-Cushing

Factors causing hyperglycemia

Hypopituitarism

Anencephaly in the fetus

Progesterone, glucocorticosteroids, phenothiazines, somatostatin, glucose

Reference values of concentration of IGFR I in blood serum

Age, years

Floor

IGFR I, ng / ml

1-3

Male

31-160

 

Women's

11-206

3-7

Male

16-288

 

Women's

70-316

7-11

Male

136-385

 

Women's

123-396

11-12

Male

136-440

 

Women's

191-462

13-14

Male

165-616

 

Women's

286-660

15-18

Male

134-836

 

Women's

152-660

18-25

Male

202-433

 

Women's

231-550

26-85

Male

135-449

Women's

135-449

The concentration of IGFR I in the blood depends on the growth hormone, and also on T 4. Low levels of IGF I detected in patients with severe impairment T 4. Carrying out substitution therapy with preparations of levothyroxine sodium leads to a normalization of the concentration of IGFR I in the blood serum.

Another factor determining the concentration of IGFR I in the blood is the nutritional status. Adequate protein-energy supply of the body is the most important condition for maintaining the normal concentration of IGFR I in the blood both in children and adults. In children with severe energy and protein deficiency, the concentration of IGFR I in the blood is reduced, but it is easily amenable to correction during normalization of nutrition. Other catabolic disorders, such as hepatic insufficiency, inflammatory bowel disease, or renal failure, are also associated with a low content of IGFR I in the blood.

In clinical practice, the study of IGFR I is important for assessing the somatotropic function of the pituitary gland.

With acromegaly, the concentration of IGFR I in the blood is constantly increased and therefore is considered a more reliable criterion for acromegaly than the content of growth hormone. The average concentration of IAPF I in the blood serum in patients with acromegaly is approximately 7 times higher than the normal age. The sensitivity and specificity of the IGFR I study for the diagnosis of acromegaly in patients over 20 years old exceeds 97%. The degree of increase in the concentration of IGFR I in the serum correlates with the activity of the disease and the growth of soft tissues. The determination of the serum level of IGFR I is used to monitor the effectiveness of treatment, as it correlates well with the residual secretion of growth hormone.

The following laboratory indicators are considered criteria for the cure of acromegaly:

  • the concentration of growth hormone in the blood on an empty stomach is less than 5 ng / ml;
  • the concentration of growth hormone in the blood is below 2 ng / ml when carrying out PTTG;
  • concentration of IGFR I in the blood within the limits of normal values.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16]

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