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Inorganic phosphorus in urine
Last reviewed: 23.04.2024
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The reference values (rate) of inorganic phosphorus release in urine in adults with a diet without its restriction are 0.4-1.3 g / day (12.9-42.0 mmol / day).
For the diagnosis of metabolic inorganic phosphorus in the body at the same time determine its content in blood serum and urine.
Hypophosphaturia is possible with a decrease in the secretion of phosphate in the distal tubules in case of hypoparathyroidism, parathyroidectomy, when the amount of glomerular filtrate is limited, in diseases such as rickets (with high calcium content in food), osteoporosis, a number of infectious diseases, acute yellow atrophy of the liver, acromegaly, phosphorus deficiency in food, large losses of phosphorus through the intestine and / or impairment of its absorption, for example, in enterocolitis. Decrease in the release of phosphate in the urine is observed in tuberculosis, febrile states, with kidney failure.
Mechanisms for increased release of phosphate in the urine are as follows.
- Phosphaturia of renal origin, caused by a violation of reabsorption of phosphorus in the proximal tubules of the kidneys, that is, with rickets that can not be treated with vitamin D, after kidney transplantation. Excretion of phosphorus more than 0.1 g / day in the presence of hypophosphatemia indicates an excessive loss of its kidneys.
- Phosphaturia of extrarenal origin, caused by primary hyperfunction of parathyroid glands, malignant tumors of bones with increased osteolysis, rickets, with increased decay of cells (eg, in leukemia).
In rickets, the amount of phosphorus released in urine increases 2-10 times in comparison with the norm. The most pronounced phosphaturia in so-called phosphate diabetes. The observed symptoms of rickets in this disease are not amenable to vitamin D therapy, massive phosphaturia in this case is an important sign for the diagnosis.
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