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Iris heterochromia: causes, symptoms, diagnosis, treatment
Alexey Kryvenko, medical expert
Last reviewed: 07.07.2025
Last reviewed: 07.07.2025
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Congenital heterochromia of the iris
- Melanocytosis of the eye.
- Oculocutaneous melanocytosis.
- Sectoral hamartoma of the iris.
- Congenital Horner's syndrome (ipsilateral hypopigmentation, miosis and ptosis).
- Waardenburg syndrome:
- autosomal dominant form I - telecanthus, protruding nasal root, partial albinism (white strands of hair), deafness; gene locus - on chromosome 2q37.3;
- autosomal dominant form II - manifestations similar to form I, accompanied by facial malformations; gene locus - on the chromosome region Зр12-р14.
- Sectoral heterochromia of the iris may accompany Hirschsprung's disease.
- Pathological changes in the iris, characterized by focal pigmentation, heterogeneous in its structure; ectropion.
[ Acquired heterochromia of the iris
- Chronic uveitis.
- Infiltration (leukemia, other tumors).
- Siderosis in the presence of an intraocular foreign body containing iron.
- Hemosiderosis (long-standing hyphema).
- Fuchs' heterochromic cyclitis (the iris on the affected side becomes lighter in color).
- Juvenile xanthogranuloma.
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