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Eye damage in ichthyosis
Last reviewed: 04.07.2025
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Ichthyosis unites a group of disorders manifested by peeling. In severe clinical cases of ichthyosis, patients die due to the addition of a widespread skin infection that is not amenable to therapy. The following forms of the disease are known:
- Ichthyosis vulgaris is an autosomal dominant disorder with no ophthalmologic manifestations.
- X-linked ichthyosis - scaling of the scalp, face, neck, abdomen and extremities; thickening of the corneal nerves and discoid keratopathy. Superficial corneal opacities may develop, opacities of the posterior layers are less common.
- Lamellar and linear ichthyosis are severe forms of the disease with an autosomal recessive type of inheritance. Eye symptoms include ectropion and keratoconjunctivitis, usually secondary in nature, caused by failure of the palpebral fissure to close.
- Epidermolysis hyperkeratosis and erythrokeratoderma are autosomal dominant disorders involving the cornea in the pathological process.
Other syndromes characterized by ichthyosis include:
- Sjogren-Larssen syndrome;
- Netherton syndrome;
- Refsum syndrome;
- Chondrodysplasia punctata;
- IBIDS syndrome;
- KIDS syndrome.
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