Common normetanephrins in the urine
Last reviewed: 23.04.2024
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The reference values (norm) of excretion in the urine of common normetanephrine are 30-440 μg / day.
Common normetanephrins are intermediate products of norepinephrine metabolism. They are determined for the purpose of diagnosing pheochromocytoma. Unlike other metabolic products of catecholamines, the content of normetanephrine in the urine is not affected by antihypertensive drugs. When evaluating the results of the study must be considered that the content of normetanephrine and metanephrine in the urine can increase after heavy exercise, hypoglycemia induced by insulin, when taking medications T 4, nephropathy, hepatitis.
The sensitivity of the determination of metanephrine and normetanephrine for the diagnosis of pheochromocytoma is 67-91%, specificity is 100%. The reliability of the diagnosis of pheochromocytoma increases if urine is collected for the study after an episode of increased blood pressure.
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