In addition to nonspecific manifestations, which are also observed in the case of nodular periarteritis (fever, loss of appetite, weight loss and malaise), the main symptom is a malfunction of the lungs. As a result, bronchial asthma begins in severe form, and darkening also occurs in the lungs, which are adhered to the X-ray of the lungs, which often quickly disappear-volatile ELI.
Among the main symptoms of the pathology is GD syndrome, which is usually a precursor of the emergence of clinical signs of systemic vasculitis. Also, infectious pathology of the lungs is frequently observed, followed by the development of bronchial asthma of an infectious-dependent type, as well as bronchiectasis. Pulmonary infiltrates are observed in 2/3 patients with the syndrome. About a third of patients are diagnosed with pleurisy with an increase in the number of eosinophils in the pleural fluid.
When lesions of the gastrointestinal tract begin to appear pain in the abdomen, as well as diarrhea and, in rare cases, bleeding. The development of these symptoms is provoked by either eosinophilic gastroenteritis or vasculitis of the intestinal wall. The latter disease can cause peritonitis, end-to-end destruction of the intestinal wall or intestinal obstruction.
Clinical manifestations of cardiac disorders occur in 1/3 of all patients, but on autopsy they are found in 62% of cases, and the cause of death is in 23% of cases. A variety of changes in the ECG readings are observed in about half of the patients. Approximately 1/3 of all cases of the disease is accompanied by the development of heart failure or pericarditis in acute or constrictive form. Occasionally, patients will notice a rise in blood pressure and myocardial infarction.
Skin diseases are observed in 70% of patients - with ESS this is a more frequent symptom than with nodular periarteritis. Among the manifestations:
- Hemorrhagic rash;
- Nodules on the skin and under the skin;
- Redness of the skin;
- Microabscesses of the skin;
- Reticular livedo.
Kidney diseases are observed less often than all other symptoms. However, they do not proceed as dangerously as in the case of Wegener's granulomatosis or nodular periarteritis. Approximately half of patients with the syndrome suffer from focal nephritis, which often becomes the cause of hypertension. In patients with antineutrophil antibodies, necrotizing glomerulonephritis may develop in the plasma.
Diseases of the joints (such as polyarthralgia or polyarthritis) occur in half of all patients with this syndrome. Usually, they develop non-progressive type migratory arthritis, which affects both small and large joints. In some cases, there is myositis or myalgia.