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Causes of high and low prealbumin

 
, medical expert
Last reviewed: 04.07.2025
 
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Prealbumin is a very sensitive negative acute-phase protein - in inflammatory processes its concentration can decrease to a level of less than 20% of the norm. Prealbumin content also decreases in nutritional deficiencies (proteins and calories), cirrhosis, liver failure and chronic liver diseases. In a combination of inflammation and nutritional deficiencies, the concentration of prealbumin in the blood serum decreases quickly and significantly.

Laboratory criteria for malnutrition

Degree of malnutrition

Indicator

Light

Average

Heavy

Albumin, g/l

Prealbumin, mg/l

Transferrin, g/l

Lymphocytes, ×10 9 /l

35-30

-

2-1.8

1.8-1.5

30-25

150-100

1.8-1.6

1.5-0.9

<25

<100

<1.6

<0.9

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