Medical expert of the article
New publications
A
A
A
Causes of increased and decreased renin
Alexey Kryvenko, Medical Reviewer, Editor
Last reviewed: 06.07.2025
Last reviewed: 06.07.2025
х
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Diseases and conditions in which plasma renin activity may be altered
Renin is low
- Excessive salt consumption
- Adrenal cortex disorders: primary hyperaldosteronism; bilateral adrenal hyperplasia; adrenal cancer
- Low renin hypertension
- Acute renal failure
- Liddle's syndrome
- Use of diuretics, glucocorticosteroids, prostaglandins, estrogens
Renin is elevated
- Secondary hyperaldosteronism
- Renal parenchyma damage
- Liver diseases (hepatitis, cirrhosis)
- Primary adrenal insufficiency (Addison's disease)
- Right ventricular failure
- Nephrosis, nephropathy
- Renal artery stenosis
- Activation of the sympathetic nervous system
- Kidney cancer with hyperreninemia
- Neuroblastoma
- Bartter's syndrome (juxtaglomerular cell hyperplasia)