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The causes of increase and decrease in immunoglobulin A
Last reviewed: 19.10.2021
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A decrease in the concentration of immunoglobulin A indicates a lack of humoral and local immunity, a violation of the synthesis or enhancement of the catabolism of immunoglobulin A, and also its adsorption on immune complexes.
Changes in the concentration of immunoglobulin A in the blood serum for various diseases
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Increase in concentration | Reduction in concentration |
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Acute and chronic bacterial, fungal and parasitic infections Chronic liver disease Cirrhosis of the liver Rheumatoid arthritis Systemic lupus erythematosus Chronic lymphatic leukemia Endothelioma, osteosarcoma Monoclonal Gammopathy Myeloma disease Waldenström's disease Candidamycosis, cystic fibrosis Diseases of the respiratory tract |
Physiological hypogammaglobulinemia (in children aged 3-5 months), congenital hypogammaglobulinemia or agammaglobulinemia Diseases that lead to the exhaustion of the immune system: Neoplasms of the immune system; condition after spleen removal; intestinal and renal protein loss syndromes; Treatment with cytostatics and immunosuppressants Acute viral, chronic bacterial infections |