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Causes of immunoglobulin A increases and decreases

 
, medical expert
Last reviewed: 04.07.2025
 
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A decrease in the concentration of immunoglobulin A indicates a deficiency of humoral and local immunity, a disruption in the synthesis or increased catabolism of immunoglobulin A, as well as its adsorption on immune complexes.

Changes in the concentration of immunoglobulin A in blood serum in various diseases

Increased concentration

Decreased concentration

Acute and chronic bacterial, fungal and parasitic infections

Chronic liver diseases

Cirrhosis

Rheumatoid arthritis

Systemic lupus erythematosus

Chronic lymphocytic leukemia

Endothelioma, osteosarcoma

Monoclonal gammopathy

Myeloma disease

Waldenstrom's disease

Candidiasis, cystic fibrosis

Respiratory diseases

Physiological hypogammaglobulinemia (in children aged 3-5 months), congenital hypogammaglobulinemia or agammaglobulinemia

Diseases that lead to depletion of the immune system:

Neoplasms of the immune system; post-splenic state; intestinal and renal protein-losing syndromes;

Treatment with cytostatics and immunosuppressants

Acute viral, chronic bacterial infections

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