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Causes of immunoglobulin A increases and decreases
Last reviewed: 04.07.2025
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A decrease in the concentration of immunoglobulin A indicates a deficiency of humoral and local immunity, a disruption in the synthesis or increased catabolism of immunoglobulin A, as well as its adsorption on immune complexes.
Changes in the concentration of immunoglobulin A in blood serum in various diseases
Increased concentration |
Decreased concentration |
Acute and chronic bacterial, fungal and parasitic infections Chronic liver diseases Cirrhosis Rheumatoid arthritis Systemic lupus erythematosus Chronic lymphocytic leukemia Endothelioma, osteosarcoma Monoclonal gammopathy Myeloma disease Waldenstrom's disease Candidiasis, cystic fibrosis Respiratory diseases |
Physiological hypogammaglobulinemia (in children aged 3-5 months), congenital hypogammaglobulinemia or agammaglobulinemia Diseases that lead to depletion of the immune system: Neoplasms of the immune system; post-splenic state; intestinal and renal protein-losing syndromes; Treatment with cytostatics and immunosuppressants Acute viral, chronic bacterial infections |