The causes of increase and decrease in immunoglobulin M
Last reviewed: 19.10.2021
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Since IgM-ATs appear in the first stage of the immune response and are mainly in the vascular bed, they play an important protective role in bacteremia in the early stages of infection. The polyvalence of these antibodies makes them particularly active in agglutination and lysis reactions. A decrease in their content indicates a lack of humoral immunity, a violation of synthesis or an increase in the catabolism of immunoglobulin M, and also its adsorption on immune complexes in inflammatory processes.
Changes in the concentration of immunoglobulin M in the blood serum for various diseases
| Increase in concentration | Reduction in concentration |
|
Acute bacterial, fungal, parasitic and viral infections Acute viral hepatitis Autoimmune diseases Cirrhosis of the liver Rheumatoid arthritis Systemic lupus erythematosus Endothelioma, osteosarcoma Myeloma disease Waldenström macroglobulinemia Candidamycosis, cystic fibrosis Diseases of the respiratory tract Monoclonal Gammopathy Acute and chronic lymphatic leukemia |
Physiological hypogammaglobulinemia (in children aged 3-5 months) Congenital hypogammaglobulinemia or agammaglobulinemia Diseases that lead to the exhaustion of the immune system:
Treatment with cytostatics and immunosuppressants, ionizing radiation Chronic viral infection Insufficiency of humoral immunity |