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Causes of immunoglobulin G increase and decrease

 
, Medical Reviewer, Editor
Last reviewed: 04.07.2025
 
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A decrease in the content of immunoglobulin G indicates a deficiency of humoral immunity.

Changes in serum immunoglobulin G concentration in various diseases

Increased concentration Decreased concentration

Acute and chronic bacterial, fungal and parasitic infections

Acute and chronic liver diseases

Liver cirrhosis, viral hepatitis

Autoimmune diseases

Rheumatoid arthritis

Collagenoses, rheumatism

Systemic lupus erythematosus

Sarcoidosis, cystic fibrosis

Waldenstrom's disease

Myeloma disease

Monoclonal gammopathy

Infectious mononucleosis

Chronic lymphocytic leukemia

Convalescence after bacterial infection

Acute period of re-infection

Physiological hypogammaglobulinemia (in children aged 3-5 months), congenital hypogammaglobulinemia or agammaglobulinemia

Hemoglobinopathies

Diseases that lead to depletion of the immune system:

  • neoplasms of the immune system;
  • condition after spleen removal;
  • intestinal and renal protein wasting syndromes

Treatment with cytostatics and immunosuppressants, ionizing radiation

Chronic viral infection

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