B-lymphocytes carrying IgA, in the blood
Last reviewed: 23.04.2024
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The normal relative amount of B-lymphocytes carrying IgA in adults is 1-3%, the absolute amount is 0.02-0.06 × 10 9 / l.
B-lymphocytes are heterogeneous in their population and perform various functions, the main one of which is Ig secretion. Mature B lymphocytes express Ig on the cell membrane. Such membrane Ig functions as antigen-specific receptors and are the most important markers of B-lymphocytes.
B-lymphocytes carrying IgA, - cells of humoral immunity, responsible for the synthesis of antibodies. They are formed in the red bone marrow and accumulate mainly in the peripheral lymphoid organs. Peripheral blood contains only 1-3% of their total number. The ratio of populations in a common B-lymphocyte pool is important in assessing humoral immunity. The violation of the ratio is characteristic for insufficiency of humoral immunity. Determination of the number of B-lymphocytes with Ig-receptors plays an important role in establishing the type of myeloma, and for lymphoproliferative diseases - to establish the localization of the block of maturation of B-lymphocytes.
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