Autism - a complication after vaccination

In many developed countries still have a question about the connection between autism and vaccination does not leave the pages of the media, reducing the coverage of immunization and promoting the conservation of measles.

In recent years in many countries it has been an increase (by 2-3 times), autism and other diseases of the spectrum (pervasive developmental disorders), the frequency of which reached 0.6% of the child population. Research in 14 regions of the US (more than 400 000 children) showed prevalence rates of 0.66% with a fluctuation range of disorders GR 33 to 1.06%, and the prevalence of boys in a ratio of 3,4-5,6 to 1 girl.

This phenomenon is most of the researchers associated with the expansion of the diagnostic framework of this disease and the improvement of the diagnostic process. However, it appeared in 1998, an article by Dr. Wakefield has put autism and chronic intestinal disorders in these children in connection with the introduction of the MMR vaccine. This hypothesis is based on individual observations, it was refuted by a number of carefully conducted studies, which were compiled two groups of scientists. In April 2008, the British Medical Council accused Dr. Wakefield's non-compliance with ethical standards in the conduct of its investigations and the actions directed against the interests of the children studied; now he is not engaged in medical activities. The charges brought against him and co-authors.

In the United States in early 2008, the government has satisfied the claim of parents a child of 9 years with mitochondrial disease and autism, grafted at the age of 18 months. MMR, but not put the development of autism in direct connection with the vaccination. This action of government has undergone medical community condemned.

It seems that the end to this matter put two recently published works. In one of them I studied the immune response to measles vaccination in 98 10-12 year-old children with autism compared to those of 148 children without autism. There was found no difference in the immune response or between groups or between children with autism, depending on the severity of symptoms. Measles virus RNA in peripheral blood monocytes was observed in 1 child with autism and 2 in the control group.

Another study examined the presence of measles virus RNA of the vaccine in the intestinal biopsies in children with intestinal disorders autism and without autism. Blinded by 3 laboratories (including the one where the hypothesis about the relationship of lymphoid hyperplasia of the mucosa and autism with vaccination was suggested initially) did not reveal any differences between the experimental and control group, as, indeed, and the time of development of autism with the introduction of vaccine.

Thiomersal - sodium thiosalicylate ethylmercury - for many years used as an antimicrobial preservative in different inactivated vaccines administered parenterally. In 1997, US Congressman F. Pallone made edits to the law, the FDA is obliged to examine the mercury preservative additives, including vaccines. At a meeting in the United States in 1999, it was reported that a child under the age of 6 months. 3 vaccine (DPT, Hib, HBV) is 187.5 mg of mercury, which is slightly, for example, compared with the amounts of mercury, received with some species of fish (in the form of methyl mercury); furthermore, there were no identifiable side effects reported thimerosal in vaccines. Nevertheless, the meeting adopted a "cautious" recommendations calling for manufacturers to consider reducing the dose of thimerosal in vaccines. I must say that this is not a logical conclusion, has caused some concern; in particular, fewer children have been vaccinated against hepatitis B in the neonatal period, which is estimated to be at risk of contracting hepatitis approximately 2,000 infants a year as a result of errors with the survey of pregnant women.

To study the possible adverse effects of thimerosal in vaccines as early as 2004, there were studies that gave a negative answer to this question. The levels of mercury in the blood of newborns, children 2 and 6 months. We were maximal within 1 day after vaccination and were, respectively, 5.0 ± 1.3, 3.6 ± 1.5 and 2.8 ± 0.9 ng / ml, they rapidly declined and returned to the introduction of vaccines by the end of the month. Isolation thimerosal occurred in the feces (respectively 19.1 ± 11.8, 37.0 ± 27.4 and 44.3 ± 23.9 ng / g, with a maximum on the 5th day) and half-time - 3.7 days. The authors conclude that the pharmacokinetics of thimerosal is different from that of methyl mercury, so that the data of the last can not be extrapolated to thimerosal.

The most complete study was psychomotor development at 42 parameters over 1 thousand children of 7-10 years. It showed that a higher dose of thimerosal received vaccine and immunoglobulin aged 0-7 months. It was associated with higher (1 point) indicators fine motor coordination, attention and self-employment. A higher dose of thimerosal aged 0-28 days was associated with a smaller (1 point) speech articulation ability, but with the large (also by 1 point) indicators fine motor coordination.

And it is quite implausible look messages about the connection between autism and thimerosal in vaccines, in spite of the persistently negative results of a number of studies on this issue. For example, in the United States in 2000-2001, there were virtually eliminated the use of vaccines with thimerosal, however, in subsequent years, been an increase in the number of autistic patients who did not receive thimerosal. An analysis of data on this subject revealed serious methodological errors, no link thimerosal in vaccines with autism has not been found. And because of the sensational reports in the media supported by fears among the population and stimulated by holding chelating therapy autistic children (about 10,000 in the US), which not only has no proven efficacy, but also can be deadly.

[1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]