Medical expert of the article
New publications
Apolipoprotein A1 in the blood serum
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Reference values (norm) of the content of apo-A 1 in serum: men - 81-169 mg / dL (0.81-1.69 g / l); women - 80-214 mg / dl (0.80-2.14 g / l).
Each primary lipoprotein is characterized by the presence in its composition of an individual, only inherent protein (apolipoprotein). Apolipoproteins are denoted in Latin letters, some of which are a family of proteins and are also indicated by numbers (for example, apo-A 1, apo-A 2, etc.). Apo-A 1 is called an "active alternative". He participates in the transport of triglycerides and cholesterol, activates lecithin-cholesterol-acetyltransferase, facilitating the reverse transport of cholesterol from the periphery (including the walls of blood vessels) to the liver. Apo-A 1 is called an "alternative" because after it enters the circulation in the chylomicron composition, it quickly enters the HDL and is integrated into these particles. In case of disruption of apo-A 1 detachment from chylomicrons, the content of HDL is reduced and the level of TG increases, which promotes the development of atherosclerosis and IHD. Due to the fact that apo-A 1 is the main apolipoprotein of a-LP, the determination of its concentration specifies the degree of risk of development of IHD in the patient. A-LP contribute to the removal of cholesterol from the vascular wall, thereby inhibiting the development of atherosclerosis.
[