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Apolipoprotein B1 in the serum
Last reviewed: 05.07.2025
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Reference values (norm) for apo-B1 levels in blood serum: men - 46-174 mg/dl (0.46-1.74 g/l); women - 46-142 mg/dl (0.46-1.42 g/l).
Apo-B is the main transporter of triglycerides from the intestine to fat cells, which is why it is called the "big loader". Increased levels of apo-B in the blood are usually combined with high LDL concentrations and are characteristic of familial LDL, which are often complicated by myocardial infarction. The basis for increased levels of apo-B in the blood in many cases is a change in its structure, which disrupts the interaction of LDL with receptors.
Currently, the determination of the concentration of apo-B is considered one of the most reliable markers of atherosclerosis. Given that apo-B is the main apolipoprotein of beta-LP, determining its concentration specifies the degree of risk of developing coronary heart disease in a patient. Beta-lipoproteins promote the penetration of cholesterol into the vascular wall. If the ratio of the concentration of apo-B to that of apo-A 1 is greater than 1, the risk of developing coronary heart disease is very high. In half of patients with coronary atherosclerosis without GLP, an increase in the ratio of apo-B/apo-A 1 (more than 1) was found, which is one of the reliable indicators of an atherogenic shift.
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