Medical expert of the article
New publications
Apolipoprotein B1 in serum
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Reference values (norm) of the content of apo-B1 in serum: men - 46-174 mg / dl (0.46-1.74 g / l); women - 46-142 mg / dl (0.46-1.42 g / l).
Apo-B is the main transporter of triglycerides from the intestine to the fat cells, so it was called the "big loader". The increase in the content of apo-B in the blood is usually combined with a high concentration of LDL and is inherent in familial HLL, which is often complicated by myocardial infarction. At the heart of the increased content of apo-B in the blood in many cases lies the change in its structure, which disrupts the interaction of LDL with the receptors.
Currently, the determination of the concentration of apo-B is considered as one of the most reliable markers of atherosclerosis. Taking into account the fact that apo-B is the main apolipoprotein of beta-LP, the determination of its concentration specifies the degree of risk of development of IHD in the patient. Beta-lipoproteins promote the penetration of cholesterol into the vascular wall. If the ratio of apo-B concentration to that of apo-A 1 is greater than 1, the risk of developing ischemic heart disease is very high. In half of patients with coronary atherosclerosis with absence of HLP, an increase in apo-B / apo-A 1 ratio (more than 1) was found, which is one of the reliable indicators of atherogenic shift.
[