Apolipoprotein B1 in serum
Last reviewed: 23.04.2024
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Reference values (norm) of the content of apo-B1 in serum: men - 46-174 mg / dl (0.46-1.74 g / l); women - 46-142 mg / dl (0.46-1.42 g / l).
Apo-B is the main transporter of triglycerides from the intestine to the fat cells, so it was called the "big loader". The increase in the content of apo-B in the blood is usually combined with a high concentration of LDL and is inherent in familial HLL, which is often complicated by myocardial infarction. At the heart of the increased content of apo-B in the blood in many cases lies the change in its structure, which disrupts the interaction of LDL with the receptors.
Currently, the determination of the concentration of apo-B is considered as one of the most reliable markers of atherosclerosis. Taking into account the fact that apo-B is the main apolipoprotein of beta-LP, the determination of its concentration specifies the degree of risk of development of IHD in the patient. Beta-lipoproteins promote the penetration of cholesterol into the vascular wall. If the ratio of apo-B concentration to that of apo-A 1 is greater than 1, the risk of developing ischemic heart disease is very high. In half of patients with coronary atherosclerosis with absence of HLP, an increase in apo-B / apo-A 1 ratio (more than 1) was found, which is one of the reliable indicators of atherogenic shift.
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