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Antibodies to single-stranded DNA in serum
Last reviewed: 18.10.2021
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Normally, the concentration of antibodies to single-stranded DNA (anthy-ssDNA) in serum is less than 300 IU / ml; 300-350 IU / ml - boundary values.
Antibodies to single-stranded DNA are detected both in rheumatic diseases and in other somatic and infectious diseases. Nevertheless, most often an increase in their titer is observed in systemic lupus erythematosus and scleroderma, especially in active and malignant forms.
The frequency of antibodies to single-stranded DNA in the blood serum with systemic lupus erythematosus and other collagenoses
|
Diseases |
Frequency of detection,% |
|
Systemic lupus erythematosus: |
65 |
|
Active |
78 |
|
Inactive |
43 |
|
Rheumatoid arthritis |
35 |
|
Systemic scleroderma |
50 |
|
Localized scleroderma |
0 |
|
Healthy |
0 |
When evaluating the results of antibodies to single- and double-stranded DNA, it should be borne in mind that many inflammatory or other processes accompanied by tissue destruction can lead to an increase in the titer of these antibodies in the blood serum.
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