Antibodies to proteinase-3 neutrophils in the blood
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Normally, there are no antibodies to protein kinase-3 neutrophils in the blood serum.
Protein kinase-3 is a neutral serine protease localized in the azurophilic granules of neutrophils. Antibodies to protein kinase-3 are most characteristic for Wegener's granulomatosis, in which they are detected in 30-99% of patients. Antibodies to PRK-3 are found in 30-40% of patients with limited or generalized forms of Wegener's granulomatosis during remission, in 70-80% of patients during the period of activity and in 80-99% of patients with active generalized forms of the disease. The diagnostic sensitivity of antibodies to protein kinase-3 against Wegener's granulomatosis varies from 30 to 99%, the specificity reaches 98%.
[