Acrodermatitis papularis of children (Gianotti-Crosti syndrome): causes, symptoms, diagnosis, treatment

Acrodermatitis papularis in children (syn. Gianotti-Crosti syndrome) is an acute disease, the development of which is associated with the hepatitis B virus, less often with other viral infections. It develops mainly in early childhood, but sometimes in adults. It is characterized by a symmetrical rash of lenticular papules on the skin of the limbs, buttocks, and face. which is affected last. Their color is pinkish or red with a bluish tint, sometimes the rash has a hemorrhagic appearance. There is usually no rash on the body or it is very weakly expressed and has an erythematosquamous character. Mild polyadenopathy is observed. acute, usually anicteric variant of hepatitis. In the blood - an insignificant monocytic reaction. Skin rashes regress after 1-2 months, and laboratory indicators indicating liver dysfunction can exist longer.

Pathomorphology of acrodermatitis papularis in children (Gianotti-Crosti syndrome). In the epidermis, there is minor acanthosis with elongation of epidermal outgrowths, focal intercellular edema, sometimes leading to the formation of vesicles, focal parakeratosis. In the dermis, there is massive edema of the papillary layer. In its upper part, there is perivascular infiltration of lymphotystiocytic nature with an admixture of eosinophils. Infiltrate cells often penetrate the edematous epidermis. Sometimes, small extravasations of erythrocytes are found in these places.

[ 1 ], [ 2 ]