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Classification of aplastic anemia
Last reviewed: 23.04.2024
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Depending on whether there is an isolated oppression of the erythroid sprout or all germs, distinguish between partial and total forms of aplastic anemia. They are accompanied respectively by isolated anemia or pancytopenia. The following variants of the disease are distinguished.
Hereditary aplastic anemia.
- Hereditary aplastic anemia with a common lesion of hemopoiesis.
- Hereditary aplastic anemia with general hematopoietic damage and congenital developmental anomalies (Fanconi anemia).
- Hereditary family aplastic anemia with a common lesion of hemopoiesis without congenital developmental anomalies (anemia of Estren-Dameshek).
- Hereditary partial aplastic anemia with selective damage to erythropoiesis (Blackfellow-Diamond anemia).
Acquired aplastic anemia.
- With a common lesion of hemopoiesis.
- Acute aplastic anemia.
- Subacute aplastic anemia.
- Chronic aplastic anemia.
- With selective lesion of erythropoiesis (partial, pure acquired red cell aplastic anemia).
The modern classification distinguishes the following forms of hematopoiesis:
Acquired anemia.
Idiopathic (87%).
Secondary (13%):
- post-virus
- Post-hepatitis (virus A, B, C) - 6%
- infection with Epstein's virus - Barr - others (Dengue, parvovirus);
- idiosyncratic (medicinal):
- levomycetin, ticlopidine, NSAIDs, etc .;
- myelotoxic (accidental): busulfan, radiation injury;
- against paroxysmal nocturnal hemoglobinuria.
- after liver transplantation for fulminant hepatitis.
Congenital anemia:
- Anemia Fanconi.
- Congenital dyskeratosis.
- Syndrome Shvakhmana-Diamond.
- Amygakaryocytic thrombocytopenia.
- Reticular dysgenesis.
- Unclassified family.
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