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The causes of increase and decrease in B-lymphocytes carrying IgG, in the blood
Last reviewed: 19.10.2021
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An increase in the number of B-lymphocytes carrying IgG in the blood is characteristic of resolving inflammatory processes. In clinical practice, when monitoring the course of the inflammatory process, it is very important to simultaneously determine the number of B-lymphocytes carrying IgM and IgG. In the usual course of the inflammatory process in its acute phase is characterized by an increase in B-lymphocytes carrying IgM; the resolution of the inflammatory process is accompanied by a decrease in the number of these lymphocytes and an increase in the content of B-lymphocytes carrying IgG. Violation of these patterns indicates a lack of humoral immunity and indicates the link due to which it is broken.
An increase in the number of B-lymphocytes carrying IgG is characteristic of myeloma, which synthesizes IgG.
Diseases and conditions leading to a change in the number of B-lymphocytes carrying IgG
- Chronic bacterial, fungal and parasitic infections
- HIV infection
- Chronic liver diseases (viral hepatitis, cirrhosis)
- Autoimmune diseases
- Rheumatoid arthritis
- Systemic lupus erythematosus
- Rheumatism, collagenoses
- Sarcoidosis, cystic fibrosis
- Waldenström's disease
- Infectious mononucleosis
- Chronic lymphatic leukemia
- Myeloma disease
- Monoclonal Gammopathy
- Reconvalence of primary bacterial infection
- Acute period of re-infection
Decrease in the indicator
- Physiological hypogammaglobulinemia (in children aged 3-5 months)
- Congenital hypogammaglobulinemia or agammaglobulinemia
- Diseases that lead to the exhaustion of the immune system:
- neoplasms of the immune system;
- treatment with cytostatics and immunosuppressants;
- ionizing radiation
- Hemoglobinopathies
- Condition after removal of spleen
- Chronic viral infection