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Uric acid in blood serum
Last reviewed: 23.04.2024
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Uric acid is a product of the exchange of purine bases, which are part of complex proteins-nucleoproteins. Formed uric acid is secreted by the kidneys. Uric acid in the extracellular fluid, including the blood plasma, is present in the form of a sodium salt (urate) in a concentration close to saturation, so it is possible to crystallize it when the maximum normal values are exceeded.
In adult men, the upper limit of the normal concentration of uric acid in the serum is 0.42 mmol / l. In an aqueous solution with pH 7.4, at a temperature of 37 ° C and an ionic strength equal to that in plasma, the solubility of sodium urate is 0.57 mmol / l; in plasma in the presence of proteins is somewhat lower. Knowledge of these constants is of great practical importance, so it allows to determine the goals of treatment for patients with gout, that is, to what level it is necessary to reduce the concentration of uric acid in the blood serum in order to achieve dissolution of urates in the extracellular fluid and tissues.
Reference values of serum uric acid concentration
|
Concentration of uric acid in blood serum | ||
|
Age |
mmol / l |
mg / dL |
|
Up to 60 years: Men Women Older than 60 years: Men Women |
0.26-0.45 0.14-0.39 0.25-0.47 0.21-0.43 |
4.4-7.6 2.3-6.6 4.2-8.0 3.5-4.2 |