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Rotavirus infection: treatment
Last reviewed: 23.04.2024
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Hospitalization is subject to patients with moderate and severe forms of rotavirus infection, as well as patients with high epidemiological risk (decreed contingents).
Complex treatment of rotavirus infection includes therapeutic nutrition, etiotropic, pathogenetic and symptomatic therapy.
From the diet exclude milk and dairy products, restrict the consumption of carbohydrates (vegetables, fruits and juices, legumes). Food should be physiologically complete, mechanically and chemically sparing, with sufficient protein, fat, mineral salts and vitamins. It is necessary to increase the multiplicity of meals.
Perspective treatment of rotavirus infection is the use of drugs that have antiviral and interferonogenic activity, in particular, meglumine acridon acetate (cycloferon). Meglumine acridon acetate in tableted form is taken on 1-2-4-6-8 day in age dosage: up to 3 years - 150 mg; 4-7 years - 300 mg; 8-12 years - 450 g: adults - 600 mg once. The use of meglumine acridon acetate results in more effective elimination of rotavirus and a reduction in the duration of the disease. In addition, immunoglobulins for enteral administration can be used as therapeutic agents: normal human immunoglobulin (IgG + IgA + IgM) - 1-2 doses 2 times a day. Antibacterial agents are not shown.
Pathogenetic treatment of rotavirus infection aimed at combating dehydration and intoxication is carried out by introducing polyionic crystalloid solutions. Intravenously or inward, taking into account the degree of dehydration and body weight of the patient. Oral rehydration is performed by warming up to 37-40 ° C solutions: glucosolan, tsitraglukosolan, regidron. For infusion therapy, polyionic solutions are used.
An effective method for the treatment of diarrhea rotavirus etiology - enterosorption: smectite dioctahedral in 1 powder 3 times a day; polimetilsiloksana polyhydrate for 1 tablespoon 3 times a day; lignin hydrolyzed by 2 tablets 3-4 times a day.
Given the enzymatic deficiency, recommend the use of polyenzymatic agents (such as pancreatin) 1-2 tablets 3 times a day during meals.
In addition, the treatment of rotavirus infection requires the inclusion of biologics containing bifidobacteria (bipiform 2 capsules 2 times a day).
[Prevention of rotavirus infection
Prevention of rotavirus infection includes a complex of anti-epidemic measures taken for the whole group of acute intestinal infections with the fecal-oral mechanism of infection. This is, first of all, rational nutrition, strict observance of sanitary norms of water supply, canalization, raising the level of sanitary and hygienic education of the population.
For the specific prevention of rotavirus infection in humans, the use of several vaccines currently undergoing the final phases of clinical trials in terms of efficacy and safety is suggested. This is Rotarix ( GlaxoSmithKline) vaccine , based on the human type of virus, and a vaccine based on human and cow rotavirus strains, created in the laboratory of Merck & Co..
Dispensary observation is not carried out.
Treatment of rotavirus infection is complemented by compliance with the diet with the restriction of milk and dairy products, carbohydrates for 2-3 weeks.