Treatment of Hemophilus Infections

Indications for hospitalization

Clinical: the presence of meningeal syndrome, respiratory failure, stenosis of the larynx, local purulent-inflammatory processes (phlegmon, cellulite, arthritis, osteomyelitis).

A mode in a hospital - bed.

Diet

Table No. 13. With epiloglotte - table number 1A, parenteral or probe nutrition.

[1], [2], [3]

Medicamentous treatment of hemophilia infection

Etiotropic treatment of hemophilic infection (generalized forms)

A drug

Daily dose, mg / kg

Multiplicity of administration, fold

The route of administration

First-line drugs

Chloramphenicol	25-50, with meningitis - 80-100	3-4	Intravenous, intramuscular
Amoxicillin-clavulanic acid	Thirty	3-4	Orally, intravenously
Cefotaxime	50-100, with meningitis - 200	4	Intravenous, intramuscular
Ceftriaxone	20-80, with meningitis - 100	1-2	Intravenous, intramuscular

Preparations of the second row

Meropenem	30, with meningitis - 120	3	Intravenously
Ciprofloxacin	20, with meningitis - 30	2	Orally, intravenously

Treatment for hemophilic infection should last at least 7-10 days.

For the treatment of localized forms, the following are also used:

• azithromycin in a dose of 10 mg / kg orally once;
• roxithromycin - 5-8 mg / kg twice per day orally;
• co-trimoxazole - 120 mg twice a day orally for 3 days.

Pathogenetic treatment of hemophilic infection is prescribed, based on clinical indications, and carried out according to general rules. With meningitis, dehydration therapy is indicated (furosemide, acetazolamide at average therapeutic doses, dexamethasone at a dose of 0.5 g / kg per day intravenously or intramuscularly).

With edema-swelling of the brain, IVL, oxygen therapy, anticonvulsants are used.

With acute epiglottitis, intubation of the trachea, loop diuretics, glucocorticoids, antihistamines are shown.

With local suppuration processes (phlegmon, osteomyelitis), surgical methods of treatment are used.

What is the prognosis of hemophilia infection?

When meningitis, septicemia, epiglottitis - hemophilic infection has a serious prognosis, with the remaining forms of Hib infection - favorable. After meningitis, persistent hearing loss is possible. Hydrocephalus-hypertensive syndrome.

Terms of incapacity for meningitis are 1-2 months after discharge from the hospital.

When Hib-meningitis is shown. Performs a neurologist, duration of at least 1 year.

Prevention of Haemophilus Infections

Specific prevention of hemophilia infection is carried out according to individual indications (frequent ARI, pathology of pregnancy and childbirth in the mother, lesions of the central nervous system in the child). Inoculation against hemophilic infection is applied :

• Act-HIB (France) in a dose of 0.5 ml intramuscularly or subcutaneously (from 2-3 to 6 months - three times with an interval of 1-2 months with a single booster at 1 year, 6 to 12 months - twice with an interval of 1 month and revaccination after 18 months, from 1 year to 5 years - once);
• Hiberici (Belgium) in a dose of 0.5 ml subcutaneously or intramuscularly (from 3 weeks to 6 months - three times at intervals of 1-2 months and a booster at 1 year, from 6 months to 1 year - twice with an interval of 1 month and a single booster through 18 months, from 1 year to 5 years - once).