Medical expert of the article
New publications
Reye's syndrome
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
[What causes Reye's syndrome?
The pathogenesis of Reye's syndrome is based on congenital mitochondrial insufficiency. The congenital defect of enzymes involved in the synthesis of urea, the ornithine cycle (ornithine transcarbaminase, carbamine phosphate synthetase, etc.) is also important. The syndrome can provoke drugs (salicylates), hepatotropic poisons and other substances.
Symptoms of Reye's Syndrome
Possible prodromal period, proceeding according to the type of ARVI or OCI. Vomiting is often the main clinical symptom before the development of coma. The peculiarity of coma in patients with Reye syndrome is an early increase in muscle tone up to the degree of decerebral rigidity. Practically all patients have badly docked tonic convulsive seizure. The meningeal symptom complex is not fully expressed, unstable. Hepatomegaly is maximally expressed by the 5th-7th day of coma development. Characteristic signs of cerebral edema.
The severity of neurological disorders in the depth of neurological disorders is divided into 4 degrees: I - somnolentia, II - sopor, III - actually coma, IV - terminal coma. The lesion can be of different degrees of severity: grade I is characterized by an increase in the activity of aminotransferases and ammonia levels, for the second degree - the addition of signs of insufficiency of the protein-synthetics function (decrease in the level of albumin, prothrombin, etc.), for III - the appearance of a hemorrhagic syndrome.
Diagnosis of Reye's syndrome
Laboratory indicators: an increase in the level of aminotransferases (2-5 times), short-term hyperammonemia (precedes coma), hypoglycemia (up to 2.5 mmol / l), hypophybrinogenemia without the presence of fibrin degradation products (no DIC), hypoalbuminemia, etc. Jaundice and hyperbilirubinemia are uncharacteristic.
Elevated levels of enzymes and ammonia remain for 3-4 days. To clarify the diagnosis of Reye's syndrome, puncture liver biopsy is often required. Children suffer mainly from the age of 3 months to 3 years.
Использованная литература