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The reasons for the increase and decrease in the average hemoglobin content in the erythrocyte
Last reviewed: 20.11.2021
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This indicator reflects the degree of saturation of the erythrocyte with hemoglobin, it can be calculated by the formula: Hb (g / l) / RBC (10 12 / l). MCH has no independent value and always correlates with MCV, color index and MCHC. Based on these indicators, anemia can be divided into normo-, hypo- and hyperchromic.
The decrease in MCH (ie, hypochromia) is characteristic of hypochromic and microcytic anemias, including iron deficiency, anemia in chronic diseases, thalassemia; some hemoglobinopathies, lead poisoning; violation of the synthesis of porphyrins.
An increase in MCH is a marker of macrocytosis and hyperchromia. Therefore, the increase in MCH is detected with megaloblastic anemia, anemia after acute hemorrhage, many chronic hemolytic anemias, hypoplastic anemia, hypothyroidism, liver diseases, metastases of malignant diseases; when taking cytotoxic drugs, oral contraceptives, anticonvulsants.