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Menetrie's disease
Last reviewed: 23.04.2024
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Disease Menetries is a rare idiopathic syndrome, observed in adults aged 30-60 years and more typical of men.
The syndrome manifests itself as a pronounced thickening of the gastric folds in the body of the stomach, but not of the antrum. Develop atrophy of glands and hyperplasia in the form of dimples, often accompanied by metaplasia of the mucous glands and thickening of the mucous membrane with a slight inflammation. There may be a hypoalbuminemia (the most constant laboratory indicator) caused by a protein loss in the digestive tract (gastropathy with loss of protein). With the progression of the disease, the production of acid and pepsin decreases, leading to hypochlorhydria.
Symptoms of Menetries
Symptoms of Menetria are non-specific and usually include epigastric pain, nausea, weight loss, swelling and diarrhea.
Diagnosis of the disease Menetries
The diagnosis of "Menetry's disease" is established with endoscopy with a biopsy of the deep layers of the mucosa or a biopsy of the entire stomach wall with laparoscopy.
Differential diagnosis of the disease Menetries includes:
- lymphoma, in which multiple gastric ulcers can develop,
- lymphoma from mucocutaneous lymphoid tissue with extensive infiltration of monoclonal B lymphocytes,
- Zollinger-Ellison syndrome with hypertrophy of the gastric folds and
- Cronkhet-Canada syndrome, which is a combination of mucosal polyposis with hypoproteinemia and diarrhea.
Treatment of Menetries disease
Different treatment of Menetriae's disease, including the use of anticholinergic, antisecretory drugs, as well as glucocorticoids, are described, but none of them has proved to be sufficiently effective. In cases of severe hypoalbuminemia, partial or complete gastrectomy is indicated.