Malondialdehyde in the blood
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Malonic dialdehyde in the blood is an unfavorable sign, since it indicates that active lipid peroxidation occurs. Normally, the serum dialdehyde malonovogo should be no more than 1 micromol / l. When free radicals break polyunsaturated fatty acids, the oxidation process goes out of control and the resulting aldehyde begins to "glue" protein amino groups. Such harmful compounds are called lipofuscin - pigment "aging". In principle, lipofuscin is present in a young organism, namely in the heart muscle, in adrenal and liver cells, in the kidneys, in the seminiferous tubules. With normal operation of all metabolic processes, this pigment does not manifest itself, but if there are various chronic diseases that deplete the body, then the level of lipofuscin significantly increases. This pigment is considered slag, since it is a consequence of finite metabolic processes. As a clinical symptom, lipofuscin is usually not considered, especially in young people. Rather, it is considered a cosmetic defect, which, incidentally, can be neutralized with adequate antioxidant therapy. However, in combination with the fact that malonic dialdehyde in the blood can be increased, the presence of pigment indicates possible intoxication, often latent, latent
Stress caused by peroxidation means inflammation of the pancreas. The etiology of the process may be different, but as a result, the active activity of free radicals is obtained with an inadequate and ineffective antioxidant function. POL (lipid peroxidation) and antioxidant work should ideally be in physiological equilibrium. If the equilibrium is violated, then as a consequence a malonic dialdehyde appears in the blood in an increased concentration, which in turn leads to a disruption of the integrity of the cell membranes.
Malone dialdehyde in blood as an analytical study confirms the diagnosis of craniocerebral trauma, pancreatitis, intestinal obstruction in acute form, severe failure - pulmonary or hepatic, myocardial infarction and various types of intoxication.
The analysis on dildehyde is prescribed for diabetes, hypertension, ischemic heart disease, atherosclerosis, ischemia of various organs, tissues. Also, malonic dialdehyde in the blood is determined in order to correct and check the effectiveness of antioxidant therapy. Also malondialdehyde in blood is dangerous for people with suspected eye diseases. Moreover, products of excessive oxidation destroy hemoglobin, the function and structure of the protein and provoke the development of lens pathology - cataract.
Malone dialdehyde in the blood as an indicator is determined by biochemical studies, the methods exist different. Many laboratories use thiobarbituric acid, as well as other reagents. A high concentration of dialdehyde in the blood is quite successfully supervised by antioxidant therapy. The choice of drugs depends on an accurate diagnosis, but after a course of treatment, malonic dialdehyde in the blood, as a rule, comes back to normal.
[