The main treatment for anaplasmosis is antibiotic therapy. The bacterium is sensitive to antibacterial drugs of the tetracycline series, so the choice often falls on Doxycycline, which patients take orally 100 mg twice a day. Duration of admission is from 10 days to three weeks. 
In addition to tetracycline drugs, anaplasma is also sensitive to amphenicol, in particular to Levomycetin. But the use of this antibiotic by specialists is not welcomed, which is associated with pronounced side effects of the drug: during treatment, patients develop granulocytopenia, leukopenia, thrombocytopenia. 
For female patients during pregnancy and lactation, the appointment of Amoxicillin or protected penicillins in individual dosages is indicated.
If antibiotics are prescribed within three days after tick suction, then a shortened course of therapy is carried out - within a week. With a later visit to the doctor, the full therapy regimen is practiced.
Additionally, symptomatic therapy is carried out, during which the following groups of drugs can be prescribed:
- non-steroidal anti-inflammatory drugs;
- antipyretic drugs;
- pain relievers;
- medicines for the correction of concomitant disorders of the respiratory, cardiovascular, nervous system.
The clinical effectiveness of the therapy is assessed by its results: a decrease in the severity and disappearance of symptoms, normalizing the dynamics of disorders in laboratory and instrumental studies, a change in the titers of specific antibodies to anaplasma are considered positive signs. If necessary, drugs are replaced and a second course of treatment is prescribed.
Most often, the following treatment regimen is used for anaplasmosis:
- Doxycycline, or its soluble analogue Unidox solutab - 100 mg twice a day;
- Amoxicillin (according to indications, or if it is impossible to use Doxycycline) - 500 mg three times a day;
- in severe anaplasmosis, the optimal drug is Ceftriaxone in the amount of 2 g intravenously 1 time per day.
Penicillin drugs, II-III generation cephalosporins, macrolides can also be considered as alternative antibiotics.
Since the use of antibiotics for anaplasmosis is usually long-term, the consequences of such therapy can be very different: most often side effects are expressed in digestive disorders, skin rashes. After the completion of the treatment course, a set of measures is necessarily prescribed to eliminate such consequences and restore the adequate functioning of the digestive system.
The most common consequence of antibiotic therapy is intestinal dysbiosis, which develops as a result of the inhibitory effect of antibacterial drugs, both on pathogens and on the natural microflora in the body. To restore such microflora, the doctor prescribes probiotics, eubiotics.
In addition to dysbiosis, prolonged antibiotic therapy can contribute to the development of fungal infections. For example, candidiasis of the oral cavity and vagina often develop.
Another possible side effect is allergies, which can be limited (rash, rhinitis) or complex (anaphylactic shock, Quincke's edema). Such conditions require urgent cancellation (replacement) of the drug and emergency antiallergic measures, using antihistamines and glucocorticoid drugs.
Along with antibiotic therapy, symptomatic drugs are prescribed. So, at elevated temperatures, severe intoxication, detoxification solutions are used, with edema - dehydration, with neuritis, arthritis and joint pain - nonsteroidal anti-inflammatory drugs and physiotherapy. Patients with a picture of damage to the cardiovascular system are prescribed Asparkam or Panangin 500 mg three times a day, Riboxin 200 mg 4 times a day.
If an immunodeficiency state is detected, Timalin is shown at 10-30 mg daily for two weeks. For patients with autoimmune manifestations - for example, with recurrent arthritis - it is recommended to take Delagil 250 mg daily in combination with non-steroidal anti-inflammatory drugs.
Vitamin therapy involves the use of preparations containing vitamins C and E.
Additionally, the treatment regimen includes vascular agents (Nicotinic acid, Complamin). To facilitate the ingress of antibacterial drugs into the central nervous system, patients are injected with Euphyllin, a glucose solution, as well as drugs to optimize cerebral circulation and nootropics (Piracetam, Cinnarizin).
In the chronic course of the disease, immunocorrective treatment is indicated.