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Haptoglobin in serum

 
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Last reviewed: 19.11.2021
 
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Haptoglobin (Hp) is a blood plasma glycoprotein that specifically binds hemoglobin. There are three hereditary phenotypes of haptoglobin: Hp 1-1, 2-1, 2-2. The first form is a monomer with a molecular weight of 85,000, the other two are polymers with a varying but much larger mass. Haptoglobin 1-1 consists of 4 polypeptide chains: 2 lungs - α-chains and 2 heavy-beta chains, interconnected by disulfide bridges.

Reference values (norm) of haptoglobin concentration in blood serum

Age

Concentration, mg / l

Newborns

50-480

6 months - 16 years

250-1380

16-60 years old

150-2000

More than 60 years

350-1750

The main physiological function of haptoglobin is the preservation of iron in the body, in addition, the hemoglobin-haptoglobin complex has a high peroxidase activity, having a retarding effect on the processes of lipid peroxidation.

trusted-source[1], [2], [3], [4], [5], [6], [7], [8], [9], [10]

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